During his PhD at the Erasmus Medical Centre, Rotterdam, Joost Rutten investigated the prognostic and diagnostic potential of the natriuretic peptides in the clinical and epidemiological setting. The natriuretic peptides are released by the heart in response to an increase in left ventricular load. The measurement of the B-type natriuretic peptides is a sensitive diagnostic test for the diagnosis of heart failure. In a clinical trial in subjects presenting to the emergency department with complaints of shortness of breath measurement of amino terminal pro B-type natriuretic peptide resulted in a reduction in length of hospital stay and costs. Furthermore, dr. Rutten demonstrated that amino terminal pro B-type natriuretic peptide has prognostic value in the general population beyond the traditional cardiovascular risk factors . As a vascular internist his research focuses on the relation between vascular stiffness and the metabolic syndrome. He participates in the research consortium "In Control", funded by "CardioVascular Onderzoek Nederland", investigating the causes of inflammation of adipose tissue, liver and blood leukocytes by focusing on the contribution of the gut microbiota. In a population based cohort the influence of inflammation of adipose tissue, liver and blood leukocytes on non invasive markers of atherosclerosis and cardiovascular risk is assessed.
Joost Rutten studied Medicine at the Faculty of Health, Medicine and Life Sciences of the Maastricht university, the Netherland, graduating in 2003. From 2003 to 2013 he worked at the Erasmus Medical Centre, Rotterdam, the Netherlands. Starting his PhD at the Department of Internal Medicine in 2004 (dr. A.H. van den Meiracker, prof. dr. A.H.J Danser). In 2007 he started his training as internist. He finished his PhD on the natriuretic peptides in 2010. He received his subspecialty training as vascular internist both at the Erasmus Medical Centre and the Radboudumc. From July 2013 he works at the department of Internal Medicine of the Radboudumc as vascular internist.