Prof. Nicole Blijlevens (Hematology) has received a KWF grant for the project: The influence of the oral microbiome and salivary proteome on oral complications in hematopoietic stem cell recipients: the H-OME study.
Oral complications are frequently encountered in autologous and allogeneic hematopoeitic stem cell transplant recipients and may have serious consequences and negatively affect quality of life. A number of risk factors for oral mucositis and oral graft-versus-host disease have been identified. However, the influence of the oral microbioom on the development of these complications is still not fully understood. The present study (H-OME) will provide information on how the oral mucositis and oral graft-versus-host disease are influenced by the oral environment. We will use next-generation high throughput laboratory techniques to determine the oral microbiome and salivary proteome in association with clinical in different cohorts of autologous and allogeneic hematopoeitic stem cell transplant recipients and compared to a database with the salivary proteome and oral microbiome of 268 healthy volunteers. By elucidating these associations we anticipate that future intervention studies directed at modifying the oral environment can be fine tuned and management strategies likewise improved.
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