IFCAH grant for "Testicular Adrenal Rest Tumor" research group

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The group consisting of Hedi Claahsen, Manon Engels, Paul Span, Teun van Herwaarden and Fred Sweep, Departments of Pediatrics, Laboratory Medicine, and Radiation Oncology, have been awarded a € 66,000 grant by the International Fund for Congenital Adrenal Hyperplasia.

The project entitled "The etiology and characteristics of testicular adrenal rest tumors (TART)" is designed to compare several transcriptome profiles, which will yield insights in the etiology of TART and provide suitable markers to discriminate TART. Congenital adrenal hyperplasia (CAH) is most often caused by a 21-hydroxylase deficiency which will results in deficient levels of cortisol and aldosterone, while testerone levels are elevated. Benign testicular adrenal rest tumors (TART) are common in pubertal and adult CAH patients and the main cause of infertility in male CAH patients. The etiology and characterization of these tumors, however still remains to be established. Current treatment with high dosages of dexamethasone is not evidence-based and only temporarily improves fertility in part of the patients with significant side effects. Furthermore, TART are sometimes misdiagnosed as Leydig cell tumors (LCT) leading to unnecessary surgery, heightening the priority for an unequivocal diagnosis.

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