As a result of a collaboration between Yvonne Hartman, Dick Thijssen (Physiology) and Cees Tack (Internal Medicine), a study entitled ‘Insulin-Associated Weight Gain in Type 2 Diabetes Is Associated With Increases in Sedentary Behavior’ was recently published in Diabetes Care. This study shows that patients with diabetes who sit more, gain more weight. The findings suggest that sedentary behavior assessment and intervention may be needed in T2D management.
Start of insulin treatment in type 2 diabetes (T2D) is associated with weight gain. We explored whether changes in sedentary behaviour (i.e. sitting), light physical activity and/or moderate-to-vigorous physical activity relate to weight gain after start of insulin therapy. We assessed weight and free-living physical activity patterns in T2D patients (n=40) before therapy and 6 and 12-months after start of therapy.
Body weight increased 2.9±4.5kg across the 12-month period (P<0.05). After 12-months, moderate-to-vigorous physical activity did not change, whilst low-intensity physical activity declined from 2.0±1.1h to 1.6±0.9h (P=0.027) and sitting time increased (11.7±1.7h to 12.3±1.9h, P=0.028). T2D patients with BMI<30kg/m2 showed a positive correlation between changes in sitting time and weight gain (r=0.446, P=0.037) and waist circumference (r=0.446, P=0.033), whilst such relations were not present in patients with BMI≥30kg/m2.
This suggests that increased sedentary behavior, especially in nonobese T2D patients, may contribute to body weight gain after initiation of insulin therapy. This finding highlights the clinical relevance of targeting sedentary behaviour in the context of T2D management.
Insulin-Associated Weight Gain in Type 2 Diabetes Is Associated With Increases in Sedentary Behavior. Hartman YAW, Jansen HJ, Hopman MTE, Tack CJ, Thijssen DHJ. Diabetes Care 2017; 40(9): e120-e121. link
<< back to overview news items